FISH Probes and Panels
Acute Lymphocytic Leukemia (ALL)
B-ALL PEDIATRIC/ADULT
WHS/CEP4 [4p16.3/4cen]
ABL/BCR [9q34/22q11.2]
p16/CEP9 [9p21/9cen]
CEP10/PTEN [10cen/10q23]
MLL BAP [11q23]
ETV6/RUNX1 [12p13/21q22]
T-cell disorders
ALK BAP [2p23]
D7S522 [7q31]
MYC/IgH/CEP8 [8q24/14q32.3/8cen]
MLL BAP [11q23]
p16/CEP9 [9p21/9cen]
TCR BAP [14q11.2]
Chronic Lymphocytic Leukemia (CLL)
ATM/p53 [11q22.3/17p13.1]
CEP12/D13S319/LAMP1 [12cen/13q14.3/13q34]
MYB/CEP6 [6q23/6cen]
CCND1/IgH [11q13/14q32.3]
Chronic Myelogenous Leukemia (CML)
ABL/BCR [9q34/22q11.2]
Multiple Myeloma (MM) CD138 with enrichment
CKS1B/p18 [1q21/1p32]
TAS2R1/CEP9/CEP15 [5p15.31/9CEN/15CEN]
D13S319/13q34[13q14.3/13q34]
IgH BAP [14q32.3]
p53/CEP10 [17p13.1/10cen]
reflex probe sets if IgH BAP is abnormal
FGFR3/IgH [4p16.3/14q32.3]
CCND1 XT/IgH[11q13/14q32.3]
IgH/MAF [14q32.3/16q23]
CCND3/IgH [6p21/14q32.3]
IgH/MAFB [14q32.3/20q12]
Myeloid Disorders (AML/MDS)
EGR1 [5q31]
D7S522 [7q31]
MECOM BAP [3q26]
MLL BAP [11q23]
PML/RARA [15q24/17q21.1]
CBFB [16q22]
RUNX1/RUNX1T1 [21q22/8q22]
p53 [17p13.1]
Glioma
LSI 1p/1q [1p36/1q25]
LSI 19p/19q [19p13/19q13]
Lipomatous neoplasms
DDIT3
MDM2
Aneuploidy screen (AneuVysion)
CEPX/Y/18 [Xp11.2q11.2,Yp11.2q11.2,18p11.2q11.2]
LSI13/21 [13q14, 21q22.13q22.2]
Lymphoma - Non-Hodgkin’s (NHL)
DLBCL: BCL6 BAP [3q27]
Burkitt: MYC BAP [8q24]
Mantle: CCND1/IgH [11q13/14q32.3]
Follicular: IgH/BCL2 [14q32.3/18q21]
MALT: IgH/MALT [14q32.2/18q21]
Myeloproliferative/Imatinib Responsive disease
FIP1L1,CHIC2,PDGFRα [4q12]
PDGFRβ BAP [5q33]
ABL/BCR [22q11.2/9q34]
FISH Microdeletion Syndromes
SRY (Yp11.3)